Observational studies show an inverse relationship between testosterone and inflammatory markers (Bianchi, 2018); and endotoxin-induced inflammation has been shown to acutely decrease TT in men (Tremellen et al., 2018); indicating increased inflammation impairs testosterone synthesis. The finding that exogenous cortisol administration and endogenous stimulation decreases TT (Cumming et al., 1983), also suggests that any hormonal effort to upregulate the urea cycle would involve an increase in cortisol, and a reciprocal decrease in testosterone. In humans, testosterone replacement therapy in hypogonadal men decreases hepatic urea production and protein loss, indicating higher levels of testosterone suppress the urea cycle (Lam et al., 2017).
Alcohol and drug abuse have negative impacts on the entire male reproductive system, including testosterone. If you’re lucky enough to live in a sunny place, a walk outside for even just 15 minutes can improve vitamin D levels. Consider meditation, journaling, or even just spending time with loved ones as ways to reduce stress.
And when an impaired exercise-induced testosterone response can go on to affect performance, growth and recovery, it’s not what lifters want. The study also highlighted evidence that testosterone didn’t just dip at rest, but that it also dropped during and after workouts. The health and fitness world is obsessed with protein – and for good reason. Different protein sources may have differential effects on TT, thus future research may also examine the effects of plant versus animal, and whole food versus powdered protein. Animal models of induced hyperammonaemia increase systemic inflammation (Balzano et al., 2020); and although not completely consistent, generally increase oxidative stress as well (Bosoi et al., 2012; Yan et al., 2021). Human and rodent studies indicate that cortisol upregulates the urea cycle (Okun et al., 2015).
Likely between 8-12oz depending on their size with a daily total close to 1g per pound of body weight. Protein-rich foods are also a great source of zinc, which is an important part of nutrition for men’s health (learn more below). Protein is crucial for building muscle, bone health, brain function, immune system function, cellular repair, blood sugar balance, and thyroid health. Otherwise, it can throw off your circadian rhythm and negatively impact gut health and hormones. We provide resources on workout nutrition, including bulking/cutting tips, meal prep, diet reviews, supplements, and more. She focuses on helping busy professionals balance healthy eating and purposeful movement. No, there is no testosterone in whey protein.
Research has demonstrated that moderate to high protein intake offer numerous benefits, such as increased satiety, weight loss, and preservation of lean mass. The commentary indicates that the testosterone decrease observed on diets exceeding 3.4 g/kg/day protein might result from a hormonal response that boosts the urea cycle. The urea cycle likely explains the testosterone decrease on very high-protein diets best. Before diving into the effects of high-protein diets on testosterone, it’s crucial to understand what constitutes a high-protein diet. Consuming adequate protein helps preserve muscle mass and prevent sarcopenia (age-related muscle loss), which is closely linked to testosterone levels. Choosing a variety of protein sources ensures that testosterone levels remain optimal while meeting nutritional needs. While other macronutrients are also necessary, ensuring an adequate protein intake helps sustain energy levels and hormonal health.
The study also noted that men’s testosterone concentration is increased directly after a heavy resistance training session. Participants in a six-week resistance training program either had a post-workout shake with 1.2g of whey protein per kg of body weight or no shake. Low-carb diets result in much higher cortisol after long-duration exercise. Notice that the study title is actually about low-carb diets and not high-protein diets. When it comes to making claims about protein and testosterone (or any subject that has been studied), we can’t take any one study out of context without considering the entire body of evidence. Physical exercise, particularly resistance training, is known to acutely elevate testosterone concentrations, while chronic training adaptations influence baseline levels . High-protein diets and testosterone.

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